This website was created as an assignment for Genetics 564 at the University of Wisconsin-Madison
Gene Ontology Project
The Gene Ontology Project was developed to help standardize terminology regarding genes, proteins, and their functions across genetics databases. The terms used, later coined GO terms, are used to search databases to make it easier to sift through information. Each GO term is split into three categories; cell component, molecular function, or biological processes. Genes and proteins are then categorized based on these three categories [1]. Scientists are able to then search databases based on these terms. For example, one can search for only genes or proteins that are localized to the ribosomes of the cell, or involved in catalytic activity, or signal transduction. These GO terms have helped scientists understand how proteins and genes interact with one another and have assisted them in mapping biological systems[1].
Gene Ontology of RYR2
EMBL-EBI was used to find the gene ontology for RYR2. For each GO category, several different terms were identified. Below is a GO term selected from cell component, molecular function, and biological processes, though there are many more listed on EMBL-EBI for each [2].
Cell Component
Molecular Function
Biological Process
Analysis
As seen in the above examples, gene ontology can help one understand how a protein is functioning within a system or how it is involved in a certain location or a function. By using these GO terms, you can find other proteins that may localize to a similar cell component and knowing this can help us understand how proteins may be interacting with each other. Gene ontology also helps us fully grasp the complexity of proteins and their functions.
References:
[1]The Gene Ontology. Accessed April 20, 2014 from http://www.geneontology.org/
[2] Quick GO on EMBL-EBI. RYR2. Accessed April 20, 2014 from http://www.ebi.ac.uk/QuickGO/
[1]The Gene Ontology. Accessed April 20, 2014 from http://www.geneontology.org/
[2] Quick GO on EMBL-EBI. RYR2. Accessed April 20, 2014 from http://www.ebi.ac.uk/QuickGO/
Site created by: Mercede Davis
Email contact: [email protected]
Date last updated: 5/14/14
Genetics 564, University of Wisconsin-Madison
Email contact: [email protected]
Date last updated: 5/14/14
Genetics 564, University of Wisconsin-Madison